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Effectiveness and safety study of formula containing probiotics, prebiotics, synbiotics on fullterm infants’ growth – a systematic review and meta-analysis of randomized controlled study

by Jiafen Qian
October 26, 2024
in Food, Nutrition, Obesity
Reading Time: 84 mins read
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Effectiveness and safety study of formula containing probiotics, prebiotics, synbiotics on fullterm infants’ growth – a systematic review and meta-analysis of randomized controlled study
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  • Hibberd AA, Yde CC, Ziegler ML, Honoré AH, Saarinen MT, Lahtinen S, et al. Probiotic or synbiotic alters the gut microbiota and metabolism in a randomised controlled trial of weight management in overweight adults. Benef Microbes. 2019;10:121–35. https://doi.org/10.3920/BM2018.0028.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Skrzydło-Radomańska B, Prozorow-Król B, Cichoż-Lach H, Majsiak E, Bierła JB, Kosikowski W, et al. The Effectiveness of Synbiotic Preparation Containing Lactobacillus and Bifidobacterium Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant Irritable Bowel Syndrome-A Randomized Double-Blind, Placebo-Controlled Study. Nutrients. 2020;12:1999 https://doi.org/10.3390/nu12071999.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Krumbeck JA, Rasmussen HE, Hutkins RW, Clarke J, Shawron K, Keshavarzian A. et al. Probiotic Bifidobacterium strains and galactooligosaccharides improve intestinal barrier function in obese adults but show no synergism when used together as synbiotics. Microbiome. 2018;6:121 https://doi.org/10.1186/s40168-018-0494-4.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu RT, Walsh RFL, Sheehan AE. Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials. Neurosci Biobehav Rev. 2019;102:13–23. https://doi.org/10.1016/j.neubiorev.2019.03.023.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Manzanares W, Lemieux M, Langlois PL, Wischmeyer PE. Probiotic and synbiotic therapy in critical illness: a systematic review and meta-analysis. Crit Care. 2016;19:262 https://doi.org/10.1186/s13054-016-1434-y.

    Article 
    PubMed 

    Google Scholar
     

  • Kanazawa A, Aida M, Yoshida Y, Kaga H, Katahira T, Suzuki L, et al. Effects of Synbiotic Supplementation on Chronic Inflammation and the Gut Microbiota in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Study. Nutrients. 2021;13:558 https://doi.org/10.3390/nu13020558.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sergeev IN, Aljutaily T, Walton G, Huarte E. Effects of Synbiotic Supplement on Human Gut Microbiota, Body Composition and Weight Loss in Obesity. Nutrients. 2020;12:222 https://doi.org/10.3390/nu12010222.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Iizumi T, Battaglia T, Ruiz V, Perez Perez GI. Gut Microbiome and Antibiotics. Arch Med Res. 2017;48:727–34. https://doi.org/10.1016/j.arcmed.2017.11.004.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Milani C, Duranti S, Bottacini F, Casey E, Turroni F, Mahony J. et al. The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota. Microbiol Mol Biol Rev. 2017;81:e00036–17. https://doi.org/10.1128/MMBR.00036-17.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kothari D, Patel S, Kim SK. Probiotic supplements might not be universally-effective and safe: A review. Biomed Pharmacother. 2019;111:537–47. https://doi.org/10.1016/j.biopha.2018.12.104.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898 https://doi.org/10.1136/bmj.l4898.

    Article 
    PubMed 

    Google Scholar
     

  • Ashley C, Johnston WH, Harris CL, Stolz SI, Wampler JL, Berseth CL. Growth and tolerance of infants fed formula supplemented with polydextrose (PDX) and/or galactooligosaccharides (GOS): double-blind, randomized, controlled trial. Nutr J. 2012 Jun;11:38. https://doi.org/10.1186/1475-2891-11-38.

  • Abrahamse-Berkeveld M, Alles M, Franke-Beckmann E, Helm K, Knecht R, Köllges R, et al. Infant formula containing galacto-and fructo-oligosaccharides and Bifidobacterium breve M-16V supports adequate growth and tolerance in healthy infants in a randomised, controlled, double-blind, prospective, multicentre study. J Nutr Sci. 2016;5:e42 https://doi.org/10.1017/jns.2016.35.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Escribano J, Ferré N, Gispert-Llaurado M, Luque V, Rubio-Torrents C, Zaragoza-Jordana M, et al. Bifidobacterium longum subsp infantis CECT7210-supplemented formula reduces diarrhea in healthy infants: a randomized controlled trial. Pediatr Res. 2018;83:1120–8. https://doi.org/10.1038/pr.2018.34.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Rodriguez-Herrera A, Mulder K, Bouritius H, Rubio R, Muñoz A, Agosti M, et al. Gastrointestinal Tolerance, Growth and Safety of a Partly Fermented Formula with Specific Prebiotics in Healthy Infants: A Double-Blind, Randomized, Controlled Trial. Nutrients. 2019;11:1530 https://doi.org/10.3390/nu11071530.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Maldonado J, Gil-Campos M, Maldonado-Lobón JA, Benavides MR, Flores-Rojas K, Jaldo R. et al. Evaluation of the safety, tolerance and efficacy of 1-year consumption of infant formula supplemented with Lactobacillus fermentum CECT5716 Lc40 or Bifidobacterium breve CECT7263: a randomized controlled trial. BMC Pediatr. 2019;19:361 https://doi.org/10.1186/s12887-019-1753-7.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Closa-Monasterolo R, Gispert-Llaurado M, Luque V, Ferre N, Rubio-Torrents C, Zaragoza-Jordana M, et al. Safety and efficacy of inulin and oligofructose supplementation in infant formula: results from a randomized clinical trial. Clin Nutr. 2013;32:918–27. https://doi.org/10.1016/j.clnu.2013.02.009.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Puccio G, Cajozzo C, Meli F, Rochat F, Grathwohl D, Steenhout P. Clinical evaluation of a new starter formula for infants containing live Bifidobacterium longum BL999 and prebiotics. Nutrition. 2007;23:1–8. https://doi.org/10.1016/j.nut.2006.09.007.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Puccio G, Alliet P, Cajozzo C, Janssens E, Corsello G, Sprenger N, et al. Effects of Infant Formula With Human Milk Oligosaccharides on Growth and Morbidity: A Randomized Multicenter Trial. J Pediatr Gastroenterol Nutr. 2017;64:624–31. https://doi.org/10.1097/MPG.0000000000001520.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Roggero P, Liotto N, Pozzi C, Braga D, Troisi J, Menis C. et al. Analysis of immune, microbiota and metabolome maturation in infants in a clinical trial of Lactobacillus paracasei CBA L74-fermented formula. Nat Commun. 2020;11:2703 https://doi.org/10.1038/s41467-020-16582-1.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Scalabrin DM, Johnston WH, Hoffman DR, P’Pool VL, Harris CL, Mitmesser SH. Growth and tolerance of healthy term infants receiving hydrolyzed infant formulas supplemented with Lactobacillus rhamnosus GG: randomized, double-blind, controlled trial. Clin Pediatr (Phila). 2009;48:734–44. https://doi.org/10.1177/0009922809332682.

    Article 
    PubMed 

    Google Scholar
     

  • Veereman-Wauters G, Staelens S, Van de Broek H, Plaskie K, Wesling F, Roger LC, et al. Physiological and bifidogenic effects of prebiotic supplements in infant formulae. J Pediatr Gastroenterol Nutr. 2011;52:763–71. https://doi.org/10.1097/MPG.0b013e3182139f39.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ziegler E, Vanderhoof JA, Petschow B, Mitmesser SH, Stolz SI, Harris CL, et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr. 2007;44:359–64. https://doi.org/10.1097/MPG.0b013e31802fca8c.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Haschke-Becher E, Brunser O, Cruchet S, Gotteland M, Haschke F, Bachmann C. Urinary D-lactate excretion in infants receiving Lactobacillus johnsonii with formula. Ann Nutr Metab. 2008;53:240–4. https://doi.org/10.1159/000185642.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Nakamura N, Gaskins HR, Collier CT, Nava GM, Rai D, Petschow B. et al. Molecular ecological analysis of fecal bacterial populations from term infants fed formula supplemented with selected blends of prebiotics. Appl Environ Microbiol. 2009;75:1121–8. https://doi.org/10.1128/AEM.02359-07.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Béghin L, Tims S, Roelofs M, Rougé C, Oozeer R, Rakza T, et al. Fermented infant formula (with Bifidobacterium breve C50 and Streptococcus thermophilus O65) with prebiotic oligosaccharides is safe and modulates the gut microbiota towards a microbiota closer to that of breastfed infants. Clin Nutr. 2021;40:778–87. https://doi.org/10.1016/j.clnu.2020.07.024.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Damien Paineau D, Respondek F, Menet V, Sauvage R, Bornet F, Wagner A. Effects of short-chain fructooligosaccharides on faecal bifidobacteria and specific immune response in formula-fed term infants: a randomized, double-blind, placebo-controlled trial. J Nutr Sci Vitaminol (Tokyo). 2014;60:167–75. https://doi.org/10.3177/jnsv.60.167.

    Article 
    PubMed 

    Google Scholar
     

  • Manzano S, De Andrés J, Castro I, Rodríguez JM, Jiménez E, Espinosa-Martos I. Safety and tolerance of three probiotic strains in healthy infants: a multi-centre randomized, double-blind, placebo-controlled trial. Benef Microbes. 2017;8:569–78. https://doi.org/10.3920/BM2017.0009.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Neumer F, Urraca O, Alonso J, Palencia J, Varea V, Theis S, et al. Long-Term Safety and Efficacy of Prebiotic Enriched Infant Formula-A Randomized Controlled Trial. Nutrients. 2021;13:1276 https://doi.org/10.3390/nu13041276.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Scalabrin DM, Mitmesser SH, Welling GW, Harris CL, Marunycz JD, Walker DC, et al. New prebiotic blend of polydextrose and galacto-oligosaccharides has a bifidogenic effect in young infants. J Pediatr Gastroenterol Nutr. 2012;54:343–52. https://doi.org/10.1097/MPG.0b013e318237ed95.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Shahramian I, Kalvandi G, Javaherizadeh H, Khalili M, Noori NM, Delaramnasab M, et al. The effects of prebiotic supplementation on weight gain, diarrhoea, constipation, fever and respiratory tract infections in the first year of life. J Paediatr Child Health. 2018;54:875–80. https://doi.org/10.1111/jpc.13906.

    Article 
    PubMed 

    Google Scholar
     

  • Ben XM, Li J, Feng ZT, Shi SY, Lu YD, Chen R, et al. Low level of galacto-oligosaccharide in infant formula stimulates growth of intestinal Bifidobacteria and Lactobacilli. World J Gastroenterol. 2008;14:6564–8. https://doi.org/10.3748/wjg.14.6564.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bruzzese E, Volpicelli M, Squeglia V, Bruzzese D, Salvini F, Bisceglia M, et al. A formula containing galacto- and fructo-oligosaccharides prevents intestinal and extra-intestinal infections: an observational study. Clin Nutr. 2009;28:156–61. https://doi.org/10.1016/j.clnu.2009.01.008.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Costalos C, Kapiki A, Apostolou M, Papathoma E. The effect of a prebiotic supplemented formula on growth and stool microbiology of term infants. Early Hum Dev. 2008;84:45–9. 10.1016/j.earlhumdev.2007.03.001.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Maldonado J, Lara-Villoslada F, Sierra S, Sempere L, Gómez M, Rodriguez JM, et al. Safety and tolerance of the human milk probiotic strain Lactobacillus salivarius CECT5713 in 6-month-old children. Nutrition. 2010;26:1082–7. https://doi.org/10.1016/j.nut.2009.08.023.

    Article 
    PubMed 

    Google Scholar
     

  • Maldonado J, Cañabate F, Sempere L, Vela F, Sánchez AR, Narbona E, et al. Human milk probiotic Lactobacillus fermentum CECT5716 reduces the incidence of gastrointestinal and upper respiratory tract infections in infants. J Pediatr Gastroenterol Nutr. 2012;54:55–61. https://doi.org/10.1097/MPG.0b013e3182333f18.

    Article 
    PubMed 

    Google Scholar
     

  • Piemontese P, Giannì ML, Braegger CP, Chirico G, Grüber C, Riedler J, et al. Tolerance and safety evaluation in a large cohort of healthy infants fed an innovative prebiotic formula: a randomized controlled trial. PLoS One. 2011;6:e28010 https://doi.org/10.1371/journal.pone.0028010.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chouraqui JP, Grathwohl D, Labaune JM, Hascoet JM, de Montgolfier I, Leclaire M, et al. Assessment of the safety, tolerance, and protective effect against diarrhea of infant formulas containing mixtures of probiotics or probiotics and prebiotics in a randomized controlled trial. Am J Clin Nutr. 2008;87:1365–73. https://doi.org/10.1093/ajcn/87.5.1365.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Meli F, Puccio G, Cajozzo C, Ricottone GL, Pecquet S, Sprenger N. et al. Growth and safety evaluation of infant formulae containing oligosaccharides derived from bovine milk: a randomized, double-blind, noninferiority trial. BMC Pediatr. 2014;14:306 https://doi.org/10.1186/s12887-014-0306-3.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sierra C, Bernal MJ, Blasco J, Martínez R, Dalmau J, Ortuño I. et al. Prebiotic effect during the first year of life in healthy infants fed formula containing GOS as the only prebiotic: a multicentre, randomised, double-blind and placebo-controlled trial. Eur J Nutr. 2015;54:89–99. https://doi.org/10.1007/s00394-014-0689-9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Moro G, Minoli I, Mosca M, Fanaro S, Jelinek J, Stahl B. et al. Dosage-related bifidogenic effects of galacto- and fructooligosaccharides in formula-fed term infants. J Pediatr Gastroenterol Nutr. 2002;34:291–5. https://doi.org/10.1097/00005176-200203000-00014.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Vlieger AM, Robroch A, van Buuren S, Kiers J, Rijkers G, Benninga MA, et al. Tolerance and safety of Lactobacillus paracasei ssp. paracasei in combination with Bifidobacterium animalis ssp. lactis in a prebiotic-containing infant formula: a randomised controlled trial. Br J Nutr. 2009;102:869–75. https://doi.org/10.1017/S0007114509289069.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Estorninos E, Lawenko RB, Palestroque E, Lebumfacil J, Marko M, Cercamondi CI. Infant formula containing bovine milk-derived oligosaccharides supports age-appropriate growth and improves stooling pattern. Pediatr Res. 2022;91:1485–92. https://doi.org/10.1038/s41390-021-01541-3.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Li X, Peng Y, Li Z, Christensen B, Heckmann AB, Stenlund H, et al. Feeding Infants Formula With Probiotics or Milk Fat Globule Membrane: A Double-Blind, Randomized Controlled Trial. Front Pediatr. 2019;7:347 https://doi.org/10.3389/fped.2019.00347.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Radke M, Picaud JC, Loui A, Cambonie G, Faas D, Lafeber HN, et al. Starter formula enriched in prebiotics and probiotics ensures normal growth of infants and promotes gut health: a randomized clinical trial. Pediatr Res. 2017;81:622–31. https://doi.org/10.1038/pr.2016.270.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kosuwon P, Lao-Araya M, Uthaisangsook S, Lay C, Bindels J, Knol J, et al. A synbiotic mixture of scGOS/lcFOS and Bifidobacterium breve M-16V increases faecal Bifidobacterium in healthy young children. Benef Microbes. 2018;9:541–52. https://doi.org/10.3920/BM2017.0110.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Bazanella M, Maier TV, Clavel T, Lagkouvardos I, Lucio M, Maldonado-Gòmez MX, et al. Randomized controlled trial on the impact of early-life intervention with bifidobacteria on the healthy infant fecal microbiota and metabolome. Am J Clin Nutr. 2017;106:1274–86. https://doi.org/10.3945/ajcn.117.157529.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Matsuki T, Tajima S, Hara T, Yahagi K, Ogawa E, Kodama H. Infant formula with galacto-oligosaccharides (OM55N) stimulates the growth of indigenous bifidobacteria in healthy term infants. Benef Microbes. 2016;7:453–61. https://doi.org/10.3920/BM2015.0168.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Colombo J, Carlson SE, Algarín C, Reyes S, Chichlowski M, Harris CL, et al. Developmental effects on sleep-wake patterns in infants receiving a cow’s milk-based infant formula with an added prebiotic blend: a Randomized Controlled Trial. Pediatr Res. 2021;89:1222–31. https://doi.org/10.1038/s41390-020-1044-x.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ivakhnenko O, Nyankovskyy SL. Effect of the specific infant formula mixture of oligosaccharides on local immunity and development of allergic and infectious disease in young children: Randomized study. Pediatr. Pol. 2013;88:398–404. https://doi.org/10.1016/j.pepo.2013.07.002.

    Article 

    Google Scholar
     

  • Kim SH, Lee DH, Meyer D. Supplementation of baby formula with native inulin has a prebiotic effect in formula-fed babies. Asia Pac J Clin Nutr. 2007;16:172–7.

    CAS 
    PubMed 

    Google Scholar
     

  • Ben XM, Zhou XY, Zhao WH, Yu WL, Pan W, Zhang WL, et al. Supplementation of milk formula with galacto-oligosaccharides improves intestinal micro-flora and fermentation in term infants. Chin Med J (Engl). 2004;117:927–31.

    CAS 
    PubMed 

    Google Scholar
     

  • Chua MC, Ben-Amor K, Lay C, Neo AGE, Chiang WC, Rao R, et al. Effect of Synbiotic on the Gut Microbiota of Cesarean Delivered Infants: A Randomized, Double-blind, Multicenter Study. J Pediatr Gastroenterol Nutr. 2017;65:102–6. https://doi.org/10.1097/MPG.0000000000001623.

    Article 
    PubMed 

    Google Scholar
     

  • Wu BB, Yang Y, Xu X, Wang WP. Effects of Bifidobacterium supplementation on intestinal microbiota composition and the immune response in healthy infants. World J Pediatr. 2016;12:177–82. https://doi.org/10.1007/s12519-015-0025-3.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Fanaro S, Jelinek J, Stahl B, Boehm G, Kock R, Vigi V. Acidic oligosaccharides from pectin hydrolysate as new component for infant formulae: effect on intestinal flora, stool characteristics, and pH. J Pediatr Gastroenterol Nutr. 2005;41:186–90. https://doi.org/10.1097/01.mpg.0000172747.64103.d7.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Anne-Judith Waligora-Dupriet AJ, Campeotto F, Nicolis I, Bonet A, Soulaines P, Dupont C, et al. Effect of oligofructose supplementation on gut microflora and well-being in young children attending a day care centre. Int J Food Microbiol. 2007;113:108–13. https://doi.org/10.1016/j.ijfoodmicro.2006.07.009.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Moro GE, Stahl B, Fanaro S, Jelinek J, Boehm G, Coppa GV. Dietary prebiotic oligosaccharides are detectable in the faeces of formula-fed infants. Acta Paediatr Suppl. 2005;94:27–30. https://doi.org/10.1111/j.1651-2227.2005.tb02151.x.

    Article 
    PubMed 

    Google Scholar
     

  • Xia Q, Williams T, Hustead D, Price P, Morrison M, Yu Z. Quantitative analysis of intestinal bacterial populations from term infants fed formula supplemented with fructo-oligosaccharides. J Pediatr Gastroenterol Nutr. 2012;55:314–20. https://doi.org/10.1097/MPG.0b013e3182523254.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Bakker-Zierikzee AM, Alles MS, Knol J, Kok FJ, Tolboom JJ, Bindels JG. Effects of infant formula containing a mixture of galacto- and fructo-oligosaccharides or viable Bifidobacterium animalis on the intestinal microflora during the first 4 months of life. Br J Nutr. 2005;94:783–90. https://doi.org/10.1079/bjn20051451.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Holscher HD, Faust KL, Czerkies LA, Litov R, Ziegler EE, Lessin H, et al. Effects of Prebiotic‐Containing Infant Formula on Gastrointestinal Tolerance and Fecal Microbiota in a Randomized Controlled Trial. J Parenter Enteral Nutr. 2012;36. https://doi.org/10.1177/0148607111430087.

  • Holscher HD, Czerkies LA, Cekola P, Litov R, Benbow M, Santema S, et al. Bifidobacterium lactis Bb12 enhances intestinal antibody response in formula-fed infants: a randomized, double-blind, controlled trial. JPEN J Parenter Enteral Nutr. 2012;36:106S–17S. https://doi.org/10.1177/0148607111430817.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Petschow BW, Figueroa R, Harris CL, Beck LB, Ziegler E, Goldin B. Effects of feeding an infant formula containing Lactobacillus GG on the colonization of the intestine: a dose-response study in healthy infants. J Clin Gastroenterol. 2005;39:786–90. https://doi.org/10.1097/01.mcg.0000177245.53753.86.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Weizman Z, Asli G, Alsheikh A. Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents. Pediatrics. 2005;115:5–9. https://doi.org/10.1542/peds.2004-1815.

    Article 
    PubMed 

    Google Scholar
     

  • Williams T, Choe Y, Price P, Katz G, Suarez F, Paule C, et al. Tolerance of formulas containing prebiotics in healthy, term infants. J Pediatr Gastroenterol Nutr. 2014;59:653–8. https://doi.org/10.1097/MPG.0000000000000513.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Indrio F, Riezzo G, Raimondi F, Bisceglia M, Cavallo L, Francavilla R. The effects of probiotics on feeding tolerance, bowel habits, and gastrointestinal motility in preterm newborns. J Pediatr. 2008;152:801–6. https://doi.org/10.1016/j.jpeds.2007.11.005.

    Article 
    PubMed 

    Google Scholar
     

  • Moro GE, Mosca F, Miniello V, Fanaro S, Jelinek J, Stahl B, et al. Effects of a new mixture of prebiotics on faecal flora and stools in term infants. Acta Paediatr Suppl. 2003;91:77–9. https://doi.org/10.1111/j.1651-2227.2003.tb00650.x.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Oswari H, Widodo AD, Handayani F, Juffrie M, Sundjaya T, Bindels J, et al. Dosage-Related Prebiotic Effects of Inulin in Formula-Fed Infants. Pediatr Gastroenterol Hepatol Nutr. 2019;22:63–71. https://doi.org/10.5223/pghn.2019.22.1.63.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Indrio F, Gutierrez Castrellon P, Vandenplas Y, Cagri Dinleyici E, Francavilla R, Mantovani MP, et al. Health Effects of Infant Formula Supplemented with Probiotics or Synbiotics in Infants and Toddlers: Systematic Review with Network Meta-Analysis. Nutrients. 2022;14:5175 https://doi.org/10.3390/nu14235175.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Vandenplas Y, De Greef E, Veereman G. Prebiotics in infant formula. Gut Microbes. 2014;5:681–7. https://doi.org/10.4161/19490976.2014.972237.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Skórka A, Pieścik-Lech M, Kołodziej M, Szajewska H. To add or not to add probiotics to infant formulae? An updated systematic review. Benef Microbes. 2017;8:717–25. https://doi.org/10.3920/BM2016.0233.

    Article 
    PubMed 

    Google Scholar
     

  • Ferro LE, Crowley LN, Bittinger K, Friedman ES, Decker JE, Russel K, et al. Effects of prebiotics, probiotics, and synbiotics on the infant gut microbiota and other health outcomes: A systematic review. Crit Rev Food Sci Nutr. 2023;63:5620–42. https://doi.org/10.1080/10408398.2021.2022595.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Venter C, Meyer RW, Greenhawt M, Pali-Schöll I, Nwaru B, Roduit C, et al. Role of dietary fiber in promoting immune health-An EAACI position paper. Allergy. 2022;77:3185–98. https://doi.org/10.1111/all.15430.

    Article 
    CAS 
    PubMed 

    Google Scholar
     




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